Merritt-Putnam Symposium | Targeted Genetic-Based Therapies of Epilepsy-General Principles and Clinical Applications

Sunday, December 5, 2021
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OVERVIEW:

This symposium aims to present basic science and expanding clinical applications of targeted genetic-based therapy.

Targeted genetic-based therapy of epilepsy includes gene therapy and gene mutation-based small molecule precision therapies.

This symposium examines these concepts in the following areas:

  1. Scientific principles underlying genetics-based therapies targeting the DNA level, therapies modulating RNA and protein expression and small molecule precision therapies targeted at modulating protein function
  2. The status of translationally relevant studies in animal models of epilepsy
  3. The current ongoing clinical studies of genetic and non-genetic symptomatic epilepsies

This session also expands on the currently in-use applications of mutation-directed precision therapy in the clinic. Specific case history examples from current clinical practice are presented as illustrations of the translational applications covered in this symposium.

Learning Objectives:

Following participation in this activity, participants will be able to:

  • Review the principles of gene therapy
  • Discuss the results of the promising gene-directed therapy approaches that have succeeded in the lab and hold promise for translation in humans
  • Recognize opportunities available for their patients' participation in ongoing clinical studies of precision therapy and gene therapy to treat epilepsy
  • Recognize how to apply gene-directed precision therapy in their clinic at the present time

Program:

Chair: Mohamad Mikati, MD

Introduction | Mohamad Mikati, MD

General Principles of Gene Therapy | Carsten Bonnemann MD

Efficacy of Gene Therapies of Epilepsy in the Laboratory | Dmitri Kullmann, FMedSci, FRS

Current Clinical Applications I: Gene and Precision Therapy Human Trials Pipeline | Orrin Devinsky, MD, FAES

Current Clinical Applications II: Precision Therapy of Epilepsy in the Clinic Today | Christelle Moufawad El Achkar, MD

Panel Discussion | All Faculty

Education Credit:

2.5 Nursing Contact Hours 

2.5 Pharmacy Contact Hours 

2.5 CME 

This educational activity is supported in part by an education grant from: Eisai Inc. 

Activity Type
Symposium
Credit
CME
CE
Format
In person
On-demand
Live streamed
Career Stage
Early Career (typically 0-5 years from completion of training)
Mid-Career (typically 6-15 years from completion of training)
Senior (typically >15 years from completion of training)
Audience
Clinicians
Scientists/Researchers
Advanced Practice Providers
Fellows/Trainees
Pharmacists
Behavioral Health Providers
Nurses
Technicians
Advocates
Demographic
Clinical
First-time Attendees
Research
Young Professionals