Investigators Workshop | The Potential of CRISPR for Treating Epilepsies
Friday, December 3, 2021
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OVERVIEW:
Gene editing, notably clustered regularly interspaced short palindromic repeates (CRISPR), is an emerging field that has the potential to impact epilepsy treatments.
In the past five years, nearly 20,000 papers containing the term CRISPR have been published, making it one of the most mainstream topics of investigation and discussion. Advances in CRISPR genome-editing engineering technologies are sparking a new revolution in biological research. In the coming years, it will likely produce tangible and potentially wide-ranging treatments and cures for genetic diseases, including some with epilepsy as a comorbidity. In this workshop, learn about CRISPR and discuss its applications from cell to organism in the lab and its implementations in the clinic, along with challenges that clinical care teams may face with CRISPR.
Learning Objectives:
Following participation in this activity, participants will be able to:
- Distinguish the CRISPR genome engineering mechanisms, tools and their various applications, and recognize it as a promising genome-editing tool for treating epilepsies
- Review CRISPR challenges, including off-target events, immune response, CRISPR tool delivery in the central nervous system (CNS), and formulate a complete strategy for performing basic genetic engineering research and designing appropriate experiments using CRISPR
- Infer the clinical implications of CRISPR, and define strategies for moving towards clinical development
Program:
Moderators: José Ángel Aibar and Franck Kalume, PhD
Speakers: Gaia Colasante, PhD, Gabriele Lignani, PhD, Aguan Wei, PhD