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Special Lecture | Lombroso Lecture: Seizure-induced Epigenetic Regulation of Cognition in Alzheimer's Disease

Monday, December 6, 2021
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OVERVIEW:

Recurrent seizures accompany a number of neurological disorders and are associated with cognitive deficits. However, the mechanisms by which seizures impair cognition have yet to be fully defined, particularly for conditions in which seizures are relatively infrequent, such as Alzheimer's disease (AD). This lecture will review recent studies demonstrating that seizures induce activity-dependent expression of ∆FosB, a transcription factor with an unusually long half-life, which epigenetically suppresses the expression of target genes that are critical for plasticity and memory. Chromatin-immunoprecipitation (ChIP) sequencing studies indicate that ∆FosB regulates several domains of neuronal function including excitability and neurotransmission, chromatin remodeling, neurogenesis, and cellular stress. These studies shed light on mechanisms by which even infrequent seizures can lead to persistent changes in neuronal function and cognition in Alzheimer's disease, with implications for other neurological disorders.

Learning Objectives:

Following participation in this activity, participants will be able to:   

  • Review the increased incidence of seizures in Alzheimer's disease 
  • Discuss mechanisms by which infrequent seizures can lead to persistent changes in cognition 
  • Identify aspects of neuronal function affected by seizure-induced epigenetic regulation. 

Program:

Basic and Clinical Science Research Award Lectures 

Basic Science Research Award Lecture, The Long and Winding Road to the Role of GABA in Focal Epileptic Disorders | Massimo Avoli, MD, PhD 

Clinical Science Research Award Lecture, MRI – A Kaleidoscope of Clinical Research | Andrea Bernasconi, MD, and Neda Bernasconi, MD, PhD

 Lombroso Lecture: Seizure-induced Epigenetic Regulation of Cognition in Alzheimer's Disease | Jeanie Chin, PhD 

Activity Type
Special Lecture
Credit
Non-CME
Format
In person
Live streamed
On-demand
Career Stage
Early Career (typically 0-5 years from completion of training)
Mid-Career (typically 6-15 years from completion of training)
Senior (typically >15 years from completion of training)
Audience
Clinicians
Scientists/Researchers
Advanced Practice Providers
Fellows/Trainees
Pharmacists
Behavioral Health Providers
Nurses
Technicians
Advocates
Demographic
Clinical
First-time Attendees
Research
Young Professionals