Scientific Symposium │ Seizures Go Virtual: Probing Mechanisms and Targeting Treatments with Multiscale Simulations
Monday, December 6, 2021
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OVERVIEW:
Hear from a panel of experts covering topics including research on channels to whole brain, how modeling can inform understanding of disease mechanisms, and patient management that highlights the power of collaborative multidisciplinary approaches to impact clinical care.
Recognizing the complex, dynamical, and multiscale nature of epilepsies; computational modeling; simulation; and quantitative approaches are emerging as important strategies to understand fundamental mechanisms, predict pathophysiology, use as tools to aid clinical/surgical decisions.
Five experts present aspects of modeling approaches being adopted in epilepsy research and management, including:
- Modeling channelopathies to understand mechanisms of epileptic encephalopathy
- Simulation of network instability in seizure transformations
- Exploring quantitative models of EEG data to localize the epileptogenic zone
- Use of personalized brain models of patients to advance explore surgical option
- A surgeon’s perspective on the application of computational method to guide patient management
Learning Objectives:
Following participation in this activity, participants will be able to:
- Recognize that computational modeling can be a powerful tool in understanding mechanisms of epilepsy at the molecular and network levels
- Discuss the ability of modeling based on patient EEG and imaging data to impact personalized medicine
- Review how cross-disciplinary approaches can be used to guide clinical decisions
- Recognize the resources and opportunities available for advancing knowledge and clinical practice based on modeling clinical data sets
Program:
Co-chairs: Viji Santhakumar, MBBS, PhD and Andrea Bernasconi, MD
Introduction | Viji Santhakumar, MBBS, PhD
Dynamic Clamp: "Wetware" in the Loop: Real Time Modeling of Sodium Channel Variants in Developmental and Epileptic Encephalopathies | Steven Petrou, PhD
Instability and Stabilization in Epileptogenic Neuronal Circuits | Scott Rich, PhD
Leveraging Dynamical Systems Models of EEG Networks to Diagnose Epilepsy and Localize the Epileptogenic Zone | Sridevi Sarma, PhD
Building Patient-Specific Brain Models as In-Silico Frameworks to Guide Clinical Decision Making in Epilepsy | Viktor Jirsa, PhD
Computational Modeling Applied to Epilepsy Surgery: Surgeon's Perspective | Kareem A. Zaghloul, MD, PhD
Panel Discussion | All Faculty
Education Credit:
3.0 Nursing Contact Hours
3.0 Pharmacy Contact Hours
3.0 CME